Saturday, December 1, 2012

Final Year Projects

When I was in NUS, as a mentor, I directed more than 40 undergraduates for their final year projects which are applied or exploratory researches in medical  device, biointerface and funcational material aeras. The projects are listed as follows:
  1. Liposomes for drug delivery in bladder cancer
  2. Nanoparticle-based intravesical therapy for bladder cancer
  3. Interaction of stem cells with nanotopography
  4. Anti-biofilm nano composites of graphene oxide
  5. Initial interaction of human bone marrow stem cells and staphylococcus epidermidis bacteria with microtopography
  6. Interactions of human bone marrow stem cells and bacteria with multilayers of chitosan derivatives on titanium
  7. Nanostructure surface interaction with bone marrow stem cells
  8. Injectable chitosan-based hydrogels/membranes for biomedical applications
  9. Magnetic nanoparticles for hyperthermia treatment of cancer
  10. Stability of peptides and growth factors immobilized on orthopedic implants
  11. Polymer-magnetite nanoparticles for cell labeling
  12. Cell-metal interactions in orthopaedic applications
  13. Bacterial attachment to superhydrophobic and hydrophilic surfaces
  14. Functionalized materials for antibiofilm applications
  15. Antibacterial properties of calcium phosphate bone cement with incorporation of chitosan nanoparticle
  16. Polyelectrolyte multilayers on metal for inhibiting biocorrosion
  17. Polyelectrolyte multilayers of chitosan and heparin on titanium for biomedical applications

Seven Basic Tools of Quality

I often utilize flow chart, check sheet in the project management in the academic research to improve the work efficiency, they are also used widely in quality management, so called Seven Basic Tools of Quality. Quality management is a field which is less involved in the academic research in universities. Total quality management needs to be considered in the initial stage in prodcut development to ensure excellent final products.

Saturday, November 3, 2012

National Medal of Technology and Innovation

Innovation product development plays a major role for supporting companies to obtain sustainable competitive advantage.

National Medal of Technology and Innovation is a good resource for industrial R&D-related staffs to know the big names in technical innovations and further learn from their experience.

Friday, November 2, 2012

Design of Experiments

Design of experiments (DOE) or experimental design is paramount important in industrial research and product development, although it is is not often used in academic research in the university. The main software tools are Minitab and JMP. Recently I studies it via online resource and two good books in DOE:

Saturday, September 8, 2012

Medical Devices - from Idea, Concept, Prototype Development to Market

A summary of my understanding of medical devices from prototype development to marke.

Business driven product development is a solid base for a company to obtain competitive advantage. Market is the final objective of products.

Medical Devices is a highly regulated industry and need multidisciplinary knowledge and skills involving medicine, materials, chemical, biology, and engineering. A successful medical device need to consider the problem and need, market size and growth, current and potential competitive products, clinical trials, intellectual property, regulatory strategy and insurance reimbursement. Quality and risk management thoughts should be run through the entire process of product development to ensure safety of effectiveness of medical devices.

Medical device development is a high-risk procedure, but the success of the product will give companies, especially start-ups, a huge return and improve the company's core competencies and a wide moat.

Summary of product development phases:

Friday, August 10, 2012

Managing Oneself

Peter F. Drucker's article "Managing Oneself" give people, especially knowledge workers inspiration and direction for career path development and life. 
Firstly, the knowledge worker should know what is his strengths, which can only be found by the feedback analysis. Whenever one makes a key decision, and whatever one does a key action, one writes down what one expects will happen. And nine months or twelve months later one then feeds back from results to expectations. After several years or short period of time, this simple procedure will tell people first where their strengths are and where they have no strengths. Then people can act to concentrate on one's strengths, improve one's strengths (waste as little effort as possible on improving areas of low competence), overcome intellectual arrogance, acquire the skills and knowledge needed to make one's strengths fully productive, and remedy one's bad habits. Particularly the feedback analysis can identify the areas where intellectual arrogance causes disabling ignorance, especially for people with high knowledge in one area who are often contemptuous of knowledge in other areas. 

Secondly, people should know how he performs (methods of learning and delivery). To know about how one performs, people need know that he is a reader or a listener, how he learn (via taking note or hear himself talk, many others), he works best as subordinates or an independent commander, he works best as a minnow in a big organization or best as a big fish in a small organization, he performs well under stress or not, he needs a highly structured and predictable environment or not, and he produces results as a decision maker or as an adviser. 

Finally, people need to know what are his values. The method is mirror test which requires to ask oneself "what kind of person do I want to see when I shave myself in the morning? One's values must be compatible with the organization's values.

Based on the answers to the three questions, people can and should decide where he belongs and what should he contribute. As Drucker summaries: "Successful careers are not planned. They develop when people are prepared for opportunities because they know their strength, their method of work, and their values." 

Besides managing oneself, the same holds true for "managing" coworkers via understanding the people you work with for making use of their strengths, their ways of working, and their values. Because we need to work with others we also need to take responsibility for our relationships. This requires us to accept other people as much as individuals as ourselves and take responsibility for communication. We should ask everyone with whom we work the following question: what do I need to know about your strengths, how you perform, your values, and your proposed contribution.

Too many people today let other people dictate what they should do in their careers. This book is a wonderful and quick way to understand how you, and the people around you, then direct people to develop their careers. Drucker always give his readers a new way of thinking.

Saturday, June 30, 2012

Patent


The patent system added the fuel of interest to the fire of genius. 
–Abraham Lincoln 

Patent is one form of intellectual property which includes trademark, copyright, and trade secret protection as well. The patent literature is one of the most comprehensive sources of technical information and represents the most valuable technology discovered by corporations, universities, and independent inventors. Patents in the industrial R&D is as important as peer-review papers in academic research, maybe even more important to the companies to obtain sustainable competitive advantage, especially to the medical device company. 

A good reference book for beginners in the industrial R&D area is Patent Fundamentals for Scientists and Engineers. Both of two authors have education backgroud in science and many years experience in the patent field either as a patent agent or a patent examiner. Certaintly, rich resource can be found in the The United States Patent and Trademark Office.

Recently, one important change of America Invents Act is adopting "first-investor-to-file" patent system instead of previous "first-to-invest" system. Finally, the US follows the rule used by all other countries.